Handrean Soran Selected Research

olipudase alfa

1/2021	Changes in PCSK 9 and apolipoprotein B100 in Niemann-Pick disease after enzyme replacement therapy with olipudase alfa.
9/2015	Successful within-patient dose escalation of olipudase alfa in acid sphingomyelinase deficiency.

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Handrean Soran Research Topics

Disease

34	Cardiovascular Diseases (Cardiovascular Disease) 05/2024 - 11/2009
24	Type 2 Diabetes Mellitus (MODY) 10/2023 - 01/2006
19	Obesity 10/2023 - 07/2013
17	Atherosclerosis 10/2023 - 08/2008
12	Inflammation (Inflammations) 11/2023 - 07/2013
12	Weight Loss (Weight Reduction) 01/2022 - 01/2013
10	Homozygous Familial Hypercholesterolemia 05/2024 - 05/2015
10	Pancreatitis 04/2024 - 01/2017
9	Morbid Obesity 03/2021 - 09/2014
8	Dyslipidemias (Dyslipidemia) 07/2021 - 01/2012
7	Hyperlipoproteinemia Type I (Lipoprotein Lipase Deficiency, Familial) 04/2024 - 01/2017
7	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2023 - 10/2010
7	Diabetic Neuropathies (Diabetic Neuropathy) 01/2023 - 01/2021
7	Peripheral Nervous System Diseases (PNS Diseases) 07/2022 - 01/2018
7	Insulin Resistance 01/2022 - 07/2013
7	Diabetes Mellitus 01/2018 - 08/2008
6	Myocardial Infarction 05/2024 - 11/2009
6	Inborn Genetic Diseases (Disease, Hereditary) 05/2024 - 11/2016
6	Hypertriglyceridemia 11/2022 - 01/2016
6	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2020 - 01/2012
4	Costello Syndrome 05/2023 - 01/2018
4	Hypertension (High Blood Pressure) 01/2020 - 08/2008
3	Hypercholesterolemia 05/2024 - 01/2012
3	Body Weight (Weight, Body) 11/2023 - 01/2017
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2021 - 01/2006
3	Infections 01/2021 - 08/2015
3	COVID-19 01/2021 - 11/2020
3	Injection Site Reaction 01/2019 - 01/2012
3	Weight Gain 01/2013 - 01/2006
2	Aortic Valve Stenosis (Aortic Stenosis) 05/2024 - 02/2024
2	Proteinuria 10/2023 - 01/2018
2	Non-alcoholic Fatty Liver Disease 10/2023 - 11/2022
2	Pain (Aches) 01/2023 - 01/2021
2	Necrosis 01/2022 - 01/2021
2	Thyrotoxicosis 01/2021 - 09/2002
2	Small Fiber Neuropathy 01/2021 - 01/2019
2	Niemann-Pick Diseases (Niemann Pick Disease) 01/2021 - 09/2015
2	Atrial Fibrillation 01/2018 - 01/2012
2	Stroke (Strokes) 01/2017 - 11/2009
2	Coronary Artery Disease (Coronary Atherosclerosis) 12/2015 - 05/2013
2	Coronary Disease (Coronary Heart Disease) 08/2015 - 01/2009
2	Flushing 06/2012 - 01/2012

Drug/Important Bio-Agent (IBA)

24	oxidized low density lipoproteinIBA 01/2022 - 08/2008
23	LipidsIBA 05/2024 - 01/2012
22	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 05/2024 - 10/2010
18	LDL CholesterolIBA 05/2024 - 07/2014
18	CholesterolIBA 05/2024 - 09/2015
18	Triglycerides (Triacylglycerol)IBA 04/2024 - 07/2014
17	Lipoproteins (Lipoprotein)IBA 05/2024 - 10/2010
13	HDL CholesterolIBA 11/2022 - 08/2012
7	ISIS 304801IBA 10/2023 - 07/2018
7	Biomarkers (Surrogate Marker)IBA 10/2023 - 01/2021
7	HDL LipoproteinsIBA 11/2022 - 09/2014
6	LDL Lipoproteins (beta Lipoproteins)IBA 02/2024 - 05/2013
6	Apolipoprotein A-I (Apolipoprotein A1)IBA 01/2022 - 05/2015
6	ApolipoproteinsIBA 01/2021 - 08/2011
6	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2006
5	Proprotein Convertase 9IBA 11/2023 - 07/2017
4	Apolipoproteins B (ApoB)IBA 01/2022 - 10/2010
4	Lipoprotein(a)IBA 01/2022 - 08/2014
4	Niacin (Nicotinic Acid)FDA LinkGeneric 11/2020 - 01/2012
4	Insulin (Novolin)FDA Link 01/2019 - 01/2006
4	LDL glycated lipoproteinsIBA 01/2016 - 01/2009
3	Ezetimibe (Zetia)FDA Link 05/2024 - 12/2016
3	Fibric Acids (Fibrates)IBA 05/2024 - 07/2014
3	Monoclonal AntibodiesIBA 05/2024 - 12/2015
3	SubtilisinIBA 05/2024 - 01/2021
3	Apolipoprotein C-IIIIBA 04/2024 - 07/2018
3	LDL Receptors (LDL Receptor)IBA 11/2023 - 01/2017
3	Aryldialkylphosphatase (Paraoxonase)IBA 01/2023 - 08/2009
3	PCSK9 InhibitorsIBA 01/2022 - 12/2016
3	C-Reactive ProteinIBA 01/2022 - 01/2015
3	AcidsIBA 01/2021 - 09/2015
3	Bile Acids and Salts (Bile Acids)IBA 11/2020 - 12/2016
3	BMS201038IBA 11/2020 - 12/2016
3	evolocumabIBA 01/2020 - 07/2017
3	CytokinesIBA 01/2019 - 07/2013
3	AdiponectinIBA 01/2017 - 07/2013
3	MK-0524IBA 09/2015 - 01/2012
2	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA 05/2024 - 01/2021
2	diazonaphthalenedisulfonic acid (NDS)IBA 07/2022 - 01/2021
2	AntibodiesIBA 01/2022 - 09/2015
2	NAD (NADH)IBA 01/2021 - 01/2018
2	MicroRNAs (MicroRNA)IBA 01/2021 - 01/2018
2	neodymium pyrocatechin disulfonate (NPD)IBA 01/2021 - 09/2015
2	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2021 - 09/2015
2	olipudase alfaIBA 01/2021 - 09/2015
2	Hormones (Hormone)IBA 01/2020 - 01/2014
2	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 01/2019 - 01/2017
2	alirocumabIBA 07/2017 - 12/2015
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2017 - 09/2014
2	AntioxidantsIBA 09/2015 - 09/2014
2	AdipokinesIBA 01/2015 - 07/2013
2	low density lipoprotein inhibitorIBA 03/2013 - 10/2010

Therapy/Procedure

29	Therapeutics 05/2024 - 01/2006
21	Bariatric Surgery 11/2023 - 07/2013
7	Blood Component Removal (Apheresis) 05/2024 - 11/2016
3	Drug Therapy (Chemotherapy) 01/2021 - 12/2016
2	Gastric Bypass (Roux-en-Y Gastric Bypass) 02/2021 - 01/2021
2	Enzyme Replacement Therapy 01/2021 - 09/2015